Homogeneous pd-catalyzed enantioselective decarboxylative protonation.
نویسندگان
چکیده
General homogeneous conditions for the palladium-catalyzed synthesis of carbonyl compounds with tertiary carbon stereocenters at the alpha-position are reported. The highly reactive catalyst tolerates a variety of substrate substitution and functionality, and generates enantioenriched cyclic ketones from racemic allyl beta-ketoester starting materials.
منابع مشابه
Unusual Allylpalladium Carboxylate Complexes: Identification of the Resting State of Catalytic Enantioselective Decarboxylative Ketone Allylic Alkylation Reactions**
Palladium poprocks: Hold on to your CO2! Enantioselective Pd-catalyzed decarboxylative alkylation of ketone enolates proceeds via η1-σ-allyl Pd-carboxylate complexes by slow loss of CO2.
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ورودعنوان ژورنال:
- Organic letters
دوره 10 6 شماره
صفحات -
تاریخ انتشار 2008